click on the names to get their biography
| Name | Term Begins | Term Ends | |
|---|---|---|---|
| Flora Azikiwe | 1 October 1963 | 16 January 1966 | |
| Victoria Aguiyi-Ironsi | 16 January 1966 | 29 July 1966 | |
| Victoria Gowon | 1 August 1966 | 29 July 1975 | |
| Ajoke Mohammed | 29 July 1975 | 13 February 1976 | |
| Esther Oluremi Obasanjo | 13 February 1976 | 1 October 1979 | |
| No First Lady, polygamist with many wives | 1 October 1979 | 31 December 1983 | |
| Safinatu Buhari | 31 December 1983 | 27 August 1985 | |
| Maryam Babangida | 27 August 1985 | 26 August 1993 | |
| Margaret Shonekan | 26 August 1993 | 17 November 1993 | |
| Maryam Abacha | 17 November 1993 | 8 June 1998 | |
| Fati Lami Abubakar | 8 June 1998 | 29 May 1999 | |
| Stella Obasanjo | 29 May 1999 | 23 October 2005 (Died in office) | |
| Office vacant | 23 October 2005 | 29 May 2007 | |
| Turai Yar'Adua | 29 May 2007 | 9 February 2010 | |
| Patience Jonathan (acting) | 9 February 2010 | 6 May 2010 | |
| Patience Jonathan | 6 May 2010 | 29 May 2015 | |
| Aisha Muhammadu Buhari | 29 May 2015 | Present |
